Far Infrared Studies in Mice
Inhibition by whole-body hyperthermia with far-infrared rays
of the growth of spontaneous mammary tumors in mice.
Udagawa Y, Nagasawa H, Kiyokawa
Anticancer Res. 1999 Sep-Oct;19(5B):4125-30.
Research Laboratory, Meiji University, Kawasaki, Japan.
To evaluate possible therapeutic benefits
of irradiation with far-infrared rays (FIR) on breast cancer, we
examined combined effects of the chronic exposure to FIR at ambient
temperature (80 - 82 degrees F) and the whole-body hyperthermia induced
by FIR (WBH) (95 - 106 degrees F) on the growth of spontaneous mammary
tumors of mice.
A high mammary tumor strain of SHN virgin mice born on the normal rack
or FIR rack were maintained on the respective racks until mammary tumor
appearance. When the mammary tumor size reached approximately 7 mm, some
mice in each group received no further treatment (Control and FIR
groups, respectively) and the remaining mice received 3 hours of WBH
each of 5 consecutive days (C + WBH and FIR + WBH groups, respectively).
There was little difference between the control and FIR groups in the
tumor growth over 10 days of examination.
On the other hand, the tumor growth was inhibited significantly in both
C + WBH and FIR + WBH groups and the degree of inhibition was similar.
The data confirmed that the chronic exposure to FIR at ambient
temperature has little effect on the growth of spontaneous mammary
tumors in mice.
WBH with FIR, however, strongly inhibited the tumor growth without
deleterious side-effects, while chronic FIR irradiation itself again had
little effect in this process. This WBH regimen may serve as a useful
animal model for long-term studies of a noninvasive treatment of breast
Effects of far-infrared ray on
behavior and some physiological parameters in mice.
Udagawa Y, Nagasawa H. In Vivo. 2000
Experimental Animal Research Laboratory, Meiji University, Kanagawa,
The effects of chronic
exposure to far-infrared ray (FIR) on reproduction, growth, behavior,
survival time and some related parameters were examined in SHN mice.
The reproductive parameters differed slightly between the females on the
normal racks and those on the FIR racks, which emitted FIR from the
ceiling. The age and body weight on the day of vaginal opening was lower
in the experimental mice born and maintained on the FIR rack than in the
control on the normal rack.
In both sexes, the levels of urinary components in the experimental
group were significantly higher than the control at 6-7 months of age.
Spontaneous motor activity of females during the light and dark phases
were higher and lower, respectively, in the experimental group than the
The survival rate was significantly higher in the experimental group
than the control.
These findings suggest that FIR has 'normalization effects' on the